Fluorescence microscopical study of 5-hydroxytryptamine storage organelles in mepacrine-incubated blood platelets of beige mice (Chediak-Higashi syndrome)

Fluorescence microscopical study of 5-hydroxytryptamine storage organelles in mepacrine-incubated blood platelets of beige mice (Chediak-Higashi syndrome)

The number and fluorescence intensity of fluorescent granules (5-HT storage organelles) of mepacrine-incubated blood platelets of beige mice (Chediak-Higashi syndrome) are decreased compared to those of control mice platelets. This indicates both quantitative and qualitative changes of the 5-HT orga...

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Veröffentlicht in:Experientia 1978-05, Vol.34 (5), p.663-664
Hauptverfasser: Lorez, H P, Da Prada, M
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Blood Platelets - metabolism
Chediak-Higashi Syndrome - blood
Histocytochemistry
Mice
Microscopy, Fluorescence
Quinacrine - metabolism
Serotonin - metabolism
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Zusammenfassung:The number and fluorescence intensity of fluorescent granules (5-HT storage organelles) of mepacrine-incubated blood platelets of beige mice (Chediak-Higashi syndrome) are decreased compared to those of control mice platelets. This indicates both quantitative and qualitative changes of the 5-HT organelles, namely a reduced number and a reduced storage capacity, respectively.
ISSN:0014-4754
1420-9071
DOI:10.1007/BF01937020