Adenylate cyclase and phosphodiesterase from brain tissue: different stabilities during incubation of cerebral cortical slices

Adenylate cyclase and phosphodiesterase from brain tissue: different stabilities during incubation of cerebral cortical slices

Adenylate cyclase and phosphodiesterase were prepared from brain slices from guinea-pig. The specific activity of adenylate cyclase declined rapidly with increasing incubation time of tissue slices, while phosphodiesterase activity was almost uneffected by the incubation of brain slices.

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Veröffentlicht in:Experientia 1978-11, Vol.34 (11), p.1432-1433
Hauptverfasser: Schultz, J, Kleefeld, G, du Moulin, A
Format: Artikel
Sprache:eng
Schlagworte:
3',5'-Cyclic-AMP Phosphodiesterases - metabolism
Adenylyl Cyclases - metabolism
Animals
Cerebral Cortex - enzymology
Drug Stability
Guinea Pigs
Time Factors
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Zusammenfassung:Adenylate cyclase and phosphodiesterase were prepared from brain slices from guinea-pig. The specific activity of adenylate cyclase declined rapidly with increasing incubation time of tissue slices, while phosphodiesterase activity was almost uneffected by the incubation of brain slices.
ISSN:0014-4754
1420-9071
DOI:10.1007/BF01932331