Distribution of the 1,25 dihydroxy-vitamin D3 receptor in the bursa of Fabricius of chicken

The vitamin D3 metabolite 1,25(OH)2D3 is probably involved in B lymphocyte ontogeny. We therefore determined the distribution of the 1,25(OH)2D3 receptor in the bursa of Fabricius and spleen cells of 7-day-old chicks, by immunohistochemistry using a monoclonal antibody against the chick intestinal c...

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Veröffentlicht in:	Experientia 1991-08, Vol.47 (8), p.838-841
Hauptverfasser:	Petrini, M, Bianchi, F, Dolfi, A, Lupetti, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - metabolism Animals Biological and medical sciences bursa of Fabricius Bursa of Fabricius - growth & development Bursa of Fabricius - metabolism Chickens chicks cholecalciferol Fundamental and applied biological sciences. Psychology Fundamental immunology Immunobiology Immunoenzyme Techniques Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation receptors Receptors, Calcitriol Receptors, Steroid - metabolism Spleen - growth & development Spleen - metabolism
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Zusammenfassung:	The vitamin D3 metabolite 1,25(OH)2D3 is probably involved in B lymphocyte ontogeny. We therefore determined the distribution of the 1,25(OH)2D3 receptor in the bursa of Fabricius and spleen cells of 7-day-old chicks, by immunohistochemistry using a monoclonal antibody against the chick intestinal cell 1,25(OH)2D3 receptor. The bursa cells of young (7-day-old) chicks contained large amounts of receptor while the spleen cells did not. The bursa cells of older (35-day-old) chicks contained fewer receptors, but the number of receptors in the spleen increased.
ISSN:	0014-4754 1420-9071
DOI:	10.1007/BF01922468