Relation between stimulus intensity and neutrophil chemotactic response

Relation between stimulus intensity and neutrophil chemotactic response

The effect of chemotactic peptides which lack chemokinetic activity has been investigated. The neutrophil response is proportional to the logarithm of the stimulus intensity, or alternatively a power function with an exponent of 0.3. Equal responses are obtained for equal ratios between the peptide...

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Veröffentlicht in:Experientia 1977-04, Vol.33 (4), p.534-536
Hauptverfasser: Keller, H U, Wissler, J H, Hess, M W, Cottier, H
Format: Artikel
Sprache:eng
Schlagworte:
Anaphylatoxins - pharmacology
Animals
Chemotaxis, Leukocyte - drug effects
Kinetics
Neutrophils - drug effects
Neutrophils - physiology
Swine
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Zusammenfassung:The effect of chemotactic peptides which lack chemokinetic activity has been investigated. The neutrophil response is proportional to the logarithm of the stimulus intensity, or alternatively a power function with an exponent of 0.3. Equal responses are obtained for equal ratios between the peptide concentration in the lower compartment and the threshold concentration. The significance of Weber-Fechner's law in leucocyte chemotaxis is discussed.
ISSN:0014-4754
1420-9071
DOI:10.1007/BF01922257