Abnormally soluble collagen produced in fibroblasts cultures

Abnormally soluble collagen produced in fibroblasts cultures

Abnormally soluble collagen is synthesized in vitro not only by skin fibroblasts of Marfan patients but also by those of patients with Ehlers-Danlos type V and cutis laxa. The excessive solubility of collagen is corrected by the addition to the culture medium of a synthetic flavonoid, (+)- catechin.

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Bibliographische Detailangaben
Veröffentlicht in:Experientia 1976-06, Vol.32 (6), p.691-693
Hauptverfasser: Francis, G, Donnelly, P V, Di Ferrante, N
Format: Artikel
Sprache:eng
Schlagworte:
Benzopyrans - pharmacology
Cells, Cultured
Collagen - metabolism
Cutis Laxa - metabolism
Ehlers-Danlos Syndrome - metabolism
Fibroblasts - metabolism
Humans
Hydroxyproline - metabolism
Marfan Syndrome - metabolism
Skin
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Zusammenfassung:Abnormally soluble collagen is synthesized in vitro not only by skin fibroblasts of Marfan patients but also by those of patients with Ehlers-Danlos type V and cutis laxa. The excessive solubility of collagen is corrected by the addition to the culture medium of a synthetic flavonoid, (+)- catechin.
ISSN:0014-4754
1420-9071
DOI:10.1007/BF01919835