The effect of ascorbic acid on cadmium accumulation in guinea pig tissues

Accumulation of cadmium in organs of guinea pigs after subchronic oral cadmium treatment (1 mg Cd/animal/24 h) was in the following order: kidneys > liver > heart > testes > brain. The preventive effects of high doses of ascorbic acid (AA) against cadmium deposition were more pronounced...

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Veröffentlicht in:	Experientia 1992-10, Vol.48 (10), p.989-991
Hauptverfasser:	KODRABOVA, J, MADARIC, A, GINTER, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Ascorbic Acid - pharmacology Biological and medical sciences Body Weight - drug effects Brain - drug effects Brain - metabolism Cadmium - pharmacokinetics Chemical and industrial products toxicology. Toxic occupational diseases Guinea Pigs Heart - drug effects Kidney - drug effects Kidney - metabolism Liver - drug effects Liver - metabolism Male Medical sciences Metals and various inorganic compounds Myocardium - metabolism Regression Analysis Spectrophotometry, Atomic Testis - drug effects Testis - metabolism Tissue Distribution Toxicology
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Beschreibung
Zusammenfassung:	Accumulation of cadmium in organs of guinea pigs after subchronic oral cadmium treatment (1 mg Cd/animal/24 h) was in the following order: kidneys > liver > heart > testes > brain. The preventive effects of high doses of ascorbic acid (AA) against cadmium deposition were more pronounced in the testes, heart and brain, and in the kidney only after short-term cadmium treatment. Ascorbic acid had no protective effect on cadmium accumulation in the liver.
ISSN:	0014-4754 1420-9071
DOI:	10.1007/BF01919148