The presence of free D-serine, D-alanine and D-proline in human plasma

Twelve neutral free amino acids, i.e. serine, threonine, glutamine, asparagine, alanine, proline, methionine, tyrosine, valine, leucine, isoleucine and phenylalanine, were surveyed for the presence of D-enantiomers in plasma samples from patients with renal diseases and from normal subjects. D-serin...

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Veröffentlicht in:	Experientia 1992-10, Vol.48 (10), p.986-988
Hauptverfasser:	NAGATA, Y, MASUI, R, AKINO, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Alanine - blood Alanine - isolation & purification Amino Acids - blood Amino Acids - isolation & purification Biological and medical sciences Chromatography, High Pressure Liquid Creatinine - blood Female Fundamental and applied biological sciences. Psychology Humans Male Metabolisms and neurohumoral controls Middle Aged Nitrogen metabolism. Proteins. Glycoproteins. Nucleic acids. Collagen Proline - blood Proline - isolation & purification Reference Values Serine - blood Serine - isolation & purification Stereoisomerism Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Zusammenfassung:	Twelve neutral free amino acids, i.e. serine, threonine, glutamine, asparagine, alanine, proline, methionine, tyrosine, valine, leucine, isoleucine and phenylalanine, were surveyed for the presence of D-enantiomers in plasma samples from patients with renal diseases and from normal subjects. D-serine, D-alanine and D-proline were found in the patient's plasma. The highest concentrations (D/L ratio) of D-serine, D-alanine and D-proline were 0.2362, 0.2087 and 0.0986, respectively. The sum of the contents of the three D-amino acid was shown to be present in the plasma proteins.
ISSN:	0014-4754 1420-9071
DOI:	10.1007/bf01919147