Central tyramine prevents hypertension in uninephrectomized DOCA-saline treated rats
Prevention of high blood pressure in uninephrectomized, DOCA-saline treated rats was observed after treatment with central tyramine precursors. We suggest that the high blood pressure is either due to relative lack of tyrosine, which might be caused by the hyperactivity of tyrosine hydroxylase, or t...
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| Veröffentlicht in: | Experientia 1977-11, Vol.33 (11), p.1430-1431 |
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| container_issue | 11 |
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| container_title | Experientia |
| container_volume | 33 |
| creator | Shalita, B Dikstein, S |
| description | Prevention of high blood pressure in uninephrectomized, DOCA-saline treated rats was observed after treatment with central tyramine precursors. We suggest that the high blood pressure is either due to relative lack of tyrosine, which might be caused by the hyperactivity of tyrosine hydroxylase, or to hypoactivity of the decarboxylase: in both cases the result is diminished tyramine synthesis. |
| doi_str_mv | 10.1007/BF01918786 |
| format | Article |
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We suggest that the high blood pressure is either due to relative lack of tyrosine, which might be caused by the hyperactivity of tyrosine hydroxylase, or to hypoactivity of the decarboxylase: in both cases the result is diminished tyramine synthesis.</description><subject>Animals</subject><subject>Blood Pressure - drug effects</subject><subject>Brain Chemistry</subject><subject>Desoxycorticosterone - pharmacology</subject><subject>Hypertension - prevention & control</subject><subject>Male</subject><subject>Methyltyrosines - pharmacology</subject><subject>Nephrectomy</subject><subject>Rats</subject><subject>Tyramine - pharmacology</subject><subject>Tyrosine - pharmacology</subject><issn>0014-4754</issn><issn>1420-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkLtOw0AQRVeIVwg01BSuKJAMM971rl2CIYAUKU2orbEzVoz8YneDFL4eR4mgGunOubc4Qlwj3COAeXiaAaaYmEQfiQmqCMIUDB6LCQCqUJlYnYsL5z4BJMSoz8RpGkmdJhOxzLjzlprAby21dcfBYPl7zFyw3g5sPXeu7rug7oJNN76HteXS9239w6vgeZE9ho6aXc1bJj9mlry7FCcVNY6vDncqPmYvy-wtnC9e37PHeVhGCfqQWWltNBuSCYJkhWmVxkyEQHGkC4LCcEEqNlVVSZaypEgVrKQxskoI5VTc7ncH239t2Pm8rV3JTUMd9xuXG6kTxCgawbs9WNreOctVPti6JbvNEfKdwfzf4AjfHFY3RcurP3SvTP4C1sBsHQ</recordid><startdate>19771115</startdate><enddate>19771115</enddate><creator>Shalita, B</creator><creator>Dikstein, S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19771115</creationdate><title>Central tyramine prevents hypertension in uninephrectomized DOCA-saline treated rats</title><author>Shalita, B ; Dikstein, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c281t-ee46676e7a38103e419f95eaa10a526ba0b7eba457fff3e33ca24be43773f8a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Animals</topic><topic>Blood Pressure - drug effects</topic><topic>Brain Chemistry</topic><topic>Desoxycorticosterone - pharmacology</topic><topic>Hypertension - prevention & control</topic><topic>Male</topic><topic>Methyltyrosines - pharmacology</topic><topic>Nephrectomy</topic><topic>Rats</topic><topic>Tyramine - pharmacology</topic><topic>Tyrosine - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shalita, B</creatorcontrib><creatorcontrib>Dikstein, S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experientia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shalita, B</au><au>Dikstein, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Central tyramine prevents hypertension in uninephrectomized DOCA-saline treated rats</atitle><jtitle>Experientia</jtitle><addtitle>Experientia</addtitle><date>1977-11-15</date><risdate>1977</risdate><volume>33</volume><issue>11</issue><spage>1430</spage><epage>1431</epage><pages>1430-1431</pages><issn>0014-4754</issn><eissn>1420-9071</eissn><abstract>Prevention of high blood pressure in uninephrectomized, DOCA-saline treated rats was observed after treatment with central tyramine precursors. We suggest that the high blood pressure is either due to relative lack of tyrosine, which might be caused by the hyperactivity of tyrosine hydroxylase, or to hypoactivity of the decarboxylase: in both cases the result is diminished tyramine synthesis.</abstract><cop>Switzerland</cop><pmid>923698</pmid><doi>10.1007/BF01918786</doi><tpages>2</tpages></addata></record> |
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| ispartof | Experientia, 1977-11, Vol.33 (11), p.1430-1431 |
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| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF01918786 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Blood Pressure - drug effects Brain Chemistry Desoxycorticosterone - pharmacology Hypertension - prevention & control Male Methyltyrosines - pharmacology Nephrectomy Rats Tyramine - pharmacology Tyrosine - pharmacology |
| title | Central tyramine prevents hypertension in uninephrectomized DOCA-saline treated rats |
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