Central tyramine prevents hypertension in uninephrectomized DOCA-saline treated rats

Central tyramine prevents hypertension in uninephrectomized DOCA-saline treated rats

Prevention of high blood pressure in uninephrectomized, DOCA-saline treated rats was observed after treatment with central tyramine precursors. We suggest that the high blood pressure is either due to relative lack of tyrosine, which might be caused by the hyperactivity of tyrosine hydroxylase, or t...

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Veröffentlicht in:Experientia 1977-11, Vol.33 (11), p.1430-1431
Hauptverfasser: Shalita, B, Dikstein, S
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Blood Pressure - drug effects
Brain Chemistry
Desoxycorticosterone - pharmacology
Hypertension - prevention & control
Male
Methyltyrosines - pharmacology
Nephrectomy
Rats
Tyramine - pharmacology
Tyrosine - pharmacology
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Zusammenfassung:Prevention of high blood pressure in uninephrectomized, DOCA-saline treated rats was observed after treatment with central tyramine precursors. We suggest that the high blood pressure is either due to relative lack of tyrosine, which might be caused by the hyperactivity of tyrosine hydroxylase, or to hypoactivity of the decarboxylase: in both cases the result is diminished tyramine synthesis.
ISSN:0014-4754
1420-9071
DOI:10.1007/BF01918786