IgG replacement therapy for primary hypogammaglobulinaemia during pregnancy : report of 9 pregnancies in 4 patients

IgG replacement therapy for primary hypogammaglobulinaemia during pregnancy : report of 9 pregnancies in 4 patients

We report the cases of four pregnant women with primary hypogammaglobulinaemia, who received intramuscular, intravenous or no replacement therapy with IgG in late pregnancy, and review the literature. Intravenous replacement administered to the mother during pregnancy produces adequate serum IgG lev...

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Veröffentlicht in:Blut 1990-03, Vol.60 (3), p.198-201
Hauptverfasser: WILLIAMS, P. E, LEEN, C. L. S, HEPPLESTON, A. D, YAP, P. L
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Agammaglobulinemia - therapy
Biological and medical sciences
Female
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunoglobulin G - administration & dosage
Immunoglobulin G - metabolism
Immunoglobulin G - therapeutic use
Immunopathology
Infant, Newborn
Injections, Intramuscular
Injections, Intravenous
Male
Maternal-Fetal Exchange
Medical sciences
Pregnancy
Pregnancy Complications, Hematologic - therapy
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Zusammenfassung:We report the cases of four pregnant women with primary hypogammaglobulinaemia, who received intramuscular, intravenous or no replacement therapy with IgG in late pregnancy, and review the literature. Intravenous replacement administered to the mother during pregnancy produces adequate serum IgG levels in the neonate, and should be the treatment of choice in this situation.
ISSN:0006-5242
1432-0584
DOI:10.1007/bf01720276