Relationship between platelet MAO activity and concentrations of 5-HIAA and HVA in cerebrospinal fluid in chronic pain patients

Platelet monoamine oxidase (MAO) activity and concentrations of 5-HIAA and HVA in the cerebrospinal fluid (CSF) were estimated in a series of 54 chronic pain patients. Platelet MAO activity was found to correlate, positively to CSF concentrations of 5-HIAA and HVA, which had been adjusted in order t...

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Veröffentlicht in:	Journal of Neural Transmission 1986-03, Vol.66 (1), p.37-46
Hauptverfasser:	KNORRING, L. V, ORELAND, L, HAGGENDAL, J, MAGNUSSON, T, ALMAY, B, JOHANSSON, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Biological and medical sciences Blood Platelets - enzymology Body Height Chronic Disease Female Homovanillic Acid - cerebrospinal fluid Humans Hydroxyindoleacetic Acid - cerebrospinal fluid Male Medical sciences Middle Aged Monoamine Oxidase - metabolism Nervous system (semeiology, syndromes) Neurology Pain - cerebrospinal fluid Pain - enzymology Pain - physiopathology Syndrome
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Zusammenfassung:	Platelet monoamine oxidase (MAO) activity and concentrations of 5-HIAA and HVA in the cerebrospinal fluid (CSF) were estimated in a series of 54 chronic pain patients. Platelet MAO activity was found to correlate, positively to CSF concentrations of 5-HIAA and HVA, which had been adjusted in order to eliminate the influence of age and body height. However, only the correlation with 5-HIAA reached a significant level. When partial correlations were sought, only the positive correlation between platelet MAO activity and CSF 5-HIAA remained. The results support the notion that platelet MAO ia a biological marker for some trait dependent property of the central serotonergic system.
ISSN:	0300-9564 1435-1463
DOI:	10.1007/BF01262956