Lipase-catalyzed synthesis of oleic acid esters of polyethylene glycol 400

Quantitative esterification of polyethylene glycol (PEG) 400 using oleic acid and Lipozyme was achieved in hexane. The effects of temperature, nature of acyl donor, substrate ratio, enzyme quantity and reaction time upon PEG esterification were examined. Nearly selective production of either PEG mon...

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Veröffentlicht in:	Biotechnology letters 1994-02, Vol.16 (2), p.163-168
Hauptverfasser:	Janssen, G.G, Haas, M.J
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology esterification fatty acid esters Fundamental and applied biological sciences. Psychology hexane Methods. Procedures. Technologies oleic acid polyethylene glycol synthesis triacylglycerol lipase
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Beschreibung
Zusammenfassung:	Quantitative esterification of polyethylene glycol (PEG) 400 using oleic acid and Lipozyme was achieved in hexane. The effects of temperature, nature of acyl donor, substrate ratio, enzyme quantity and reaction time upon PEG esterification were examined. Nearly selective production of either PEG monooleate or PEG dioleate was achieved. Lipozyme was still 80% active after five reaction cycles.
ISSN:	0141-5492 1573-6776
DOI:	10.1007/BF01021665