Effects of ionizing radiations on human costal cartilage and exploration of the procedures to protect the tissue from radiation damage
The chemical changes produced following 60Co-gamma-irradiation of human costal cartilage have been monitored using "critical electrolyte concentration" (CEC) measurements utilizing Alcian Blue--magnesium chloride and Toluidine Blue--sodium chloride systems. The decrease in the CEC with rad...
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| Veröffentlicht in: | The Histochemical journal 1978-07, Vol.10 (4), p.389-397 |
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| container_title | The Histochemical journal |
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| creator | Edwards, H E Moore, J S Phillips, G O |
| description | The chemical changes produced following 60Co-gamma-irradiation of human costal cartilage have been monitored using "critical electrolyte concentration" (CEC) measurements utilizing Alcian Blue--magnesium chloride and Toluidine Blue--sodium chloride systems. The decrease in the CEC with radiation can be related to the decrease in hexose and hexosamine contents of the cartilage. Such changes arise as a result of degradation of the glycosaminoglycan component of the tissue. The state of the collagen fibres after irradiation has been examined using the Van Giesson stain and by biochemical assay of the hydroxyproline moeity. Energy transfer methods have been utilized to protect the glycosaminoglycan component of the cartilage from radiation damage. |
| doi_str_mv | 10.1007/BF01003002 |
| format | Article |
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The decrease in the CEC with radiation can be related to the decrease in hexose and hexosamine contents of the cartilage. Such changes arise as a result of degradation of the glycosaminoglycan component of the tissue. The state of the collagen fibres after irradiation has been examined using the Van Giesson stain and by biochemical assay of the hydroxyproline moeity. Energy transfer methods have been utilized to protect the glycosaminoglycan component of the cartilage from radiation damage.</description><subject>Aged</subject><subject>Alcian Blue</subject><subject>Cartilage - radiation effects</subject><subject>Connective Tissue - radiation effects</subject><subject>Glycosaminoglycans - radiation effects</subject><subject>Hexosamines - radiation effects</subject><subject>Humans</subject><subject>Hydroxyproline - radiation effects</subject><subject>Radiation Injuries - prevention & control</subject><subject>Ribs - radiation effects</subject><subject>Tolonium Chloride</subject><issn>0018-2214</issn><issn>1573-6865</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkD9PwzAUxC3Ev1BYmBk8IwVsJ7bjEaoWkCqxwBy92E4blMSR7UjAB-Bzk7aITqe799M96RC6puSOEiLvH5dk0owQdoQSymWWikLwY5QQQouUMZqfo4sQPgghSkpxhk6FUKqgCfpZ1LXVMWBX48b1zXfTr7EH00Cc7BT3eDN20GPtQoQWa_CxaWFtMfQG28-hdX6HbgvixuLBO23N6G3A0W1dnOp3l9iEMFpce9cdPmAD3dR2iU5qaIO9-tMZel8u3ubP6er16WX-sEo1K2hMhWaZIpBLo4wWYIymUjHIc86nmCvOKDArq0pSpoHbIudCF8JWXBuqjcpm6Hbfq70Lwdu6HHzTgf8qKSm3U5aHKSf4Zg8PY9VZ84_ut8t-AV2VcPY</recordid><startdate>197807</startdate><enddate>197807</enddate><creator>Edwards, H E</creator><creator>Moore, J S</creator><creator>Phillips, G O</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>197807</creationdate><title>Effects of ionizing radiations on human costal cartilage and exploration of the procedures to protect the tissue from radiation damage</title><author>Edwards, H E ; Moore, J S ; Phillips, G O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c281t-6c2390a47d9dc6addc1792a445590a59521a2e7bb712ca5e8456c86eb5cd1cd93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Aged</topic><topic>Alcian Blue</topic><topic>Cartilage - radiation effects</topic><topic>Connective Tissue - radiation effects</topic><topic>Glycosaminoglycans - radiation effects</topic><topic>Hexosamines - radiation effects</topic><topic>Humans</topic><topic>Hydroxyproline - radiation effects</topic><topic>Radiation Injuries - prevention & control</topic><topic>Ribs - radiation effects</topic><topic>Tolonium Chloride</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Edwards, H E</creatorcontrib><creatorcontrib>Moore, J S</creatorcontrib><creatorcontrib>Phillips, G O</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>The Histochemical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Edwards, H E</au><au>Moore, J S</au><au>Phillips, G O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of ionizing radiations on human costal cartilage and exploration of the procedures to protect the tissue from radiation damage</atitle><jtitle>The Histochemical journal</jtitle><addtitle>Histochem J</addtitle><date>1978-07</date><risdate>1978</risdate><volume>10</volume><issue>4</issue><spage>389</spage><epage>397</epage><pages>389-397</pages><issn>0018-2214</issn><eissn>1573-6865</eissn><abstract>The chemical changes produced following 60Co-gamma-irradiation of human costal cartilage have been monitored using "critical electrolyte concentration" (CEC) measurements utilizing Alcian Blue--magnesium chloride and Toluidine Blue--sodium chloride systems. The decrease in the CEC with radiation can be related to the decrease in hexose and hexosamine contents of the cartilage. Such changes arise as a result of degradation of the glycosaminoglycan component of the tissue. The state of the collagen fibres after irradiation has been examined using the Van Giesson stain and by biochemical assay of the hydroxyproline moeity. Energy transfer methods have been utilized to protect the glycosaminoglycan component of the cartilage from radiation damage.</abstract><cop>Netherlands</cop><pmid>669981</pmid><doi>10.1007/BF01003002</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0018-2214 |
| ispartof | The Histochemical journal, 1978-07, Vol.10 (4), p.389-397 |
| issn | 0018-2214 1573-6865 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF01003002 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Aged Alcian Blue Cartilage - radiation effects Connective Tissue - radiation effects Glycosaminoglycans - radiation effects Hexosamines - radiation effects Humans Hydroxyproline - radiation effects Radiation Injuries - prevention & control Ribs - radiation effects Tolonium Chloride |
| title | Effects of ionizing radiations on human costal cartilage and exploration of the procedures to protect the tissue from radiation damage |
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