Effect of defensin on platelet functional activity

The effects of human neutrophil peptide defensin were studied on human platelet function. Defensin (0.1-40 micrograms/mL) did not promote platelet aggregation. Defensin decreased platelet aggregation responses to ADF, collagen or thrombin. Defensin significantly lessened ATP level, released during p...

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Veröffentlicht in:	Biulleten' eksperimental'noi biologii i meditsiny 1993-01, Vol.115 (1), p.23-25
Hauptverfasser:	Ashmarin, I P, Tkachenko, S B, Rud'ko, I A, Korneva, E A, Kokriakov, V N, Kubatiev, A A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - pharmacology Adenosine Triphosphate - blood Blood Proteins - pharmacology Cell Communication - drug effects Collagen - pharmacology Defensins Humans Malondialdehyde - blood Neutrophils - drug effects Platelet Activation - drug effects Platelet Aggregation Inhibitors - pharmacology Thrombin - pharmacology
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