Effect of defensin on platelet functional activity

The effects of human neutrophil peptide defensin were studied on human platelet function. Defensin (0.1-40 micrograms/mL) did not promote platelet aggregation. Defensin decreased platelet aggregation responses to ADF, collagen or thrombin. Defensin significantly lessened ATP level, released during p...

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Veröffentlicht in:	Biulleten' eksperimental'noi biologii i meditsiny 1993-01, Vol.115 (1), p.23-25
Hauptverfasser:	Ashmarin, I P, Tkachenko, S B, Rud'ko, I A, Korneva, E A, Kokriakov, V N, Kubatiev, A A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - pharmacology Adenosine Triphosphate - blood Blood Proteins - pharmacology Cell Communication - drug effects Collagen - pharmacology Defensins Humans Malondialdehyde - blood Neutrophils - drug effects Platelet Activation - drug effects Platelet Aggregation Inhibitors - pharmacology Thrombin - pharmacology
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Zusammenfassung:	The effects of human neutrophil peptide defensin were studied on human platelet function. Defensin (0.1-40 micrograms/mL) did not promote platelet aggregation. Defensin decreased platelet aggregation responses to ADF, collagen or thrombin. Defensin significantly lessened ATP level, released during platelet aggregation, and malondialdehyde production, induced by thrombin and collagen. These data reveal that defensins involve in cell-cell interaction between platelets and neutrophils counteracting agonist-induced platelet activation.
ISSN:	0365-9615 0007-4888 1573-8221
DOI:	10.1007/BF00846346