Effect of the antiulcerative action (central or peripheral) of the synthetic enkephalin analog dalargin in experimental cysteamine-induced duodenal ulcer in rats

Effect of the antiulcerative action (central or peripheral) of the synthetic enkephalin analog dalargin in experimental cysteamine-induced duodenal ulcer in rats

The authors seek to establish the role of central and peripheral opiate receptors in the antiulcerative action of Dalargin. Rats were used in the experiments. A separate experiment was undertaken to study the passage of Dalargin through the blood-brain barrier. For this, the rats were injected with...

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Veröffentlicht in:Bull. Exp. Biol. Med. (Engl. Transl.); (United States) 1987-04, Vol.103 (4), p.488-490
Hauptverfasser: Polonskii, V. M., Yarygin, K. N., Krivosheev, O. G., Moskovkin, G. N., Vinogradov, V. A.
Format: Artikel
Sprache:eng
Schlagworte:
550201 - Biochemistry- Tracer Techniques
AMINES
ANIMAL CELLS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BASIC BIOLOGICAL SCIENCES
BINDING ENERGY
BIOLOGICAL EFFECTS
BIOLOGICAL PATHWAYS
BLOOD-BRAIN BARRIER
BODY
CHEMICAL COMPOSITION
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ENDORPHINS
ENERGY
ENKEPHALINS
GASTROINTESTINAL TRACT
INTESTINES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LABELLING
MAMMALS
MEA
MEMBRANE PROTEINS
NERVE CELLS
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PATHOGENESIS
PATHOLOGICAL CHANGES
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIOACTIVITY
RADIONUCLIDE KINETICS
RADIOPROTECTIVE SUBSTANCES
RADIORECEPTOR ASSAY
RATS
RECEPTORS
RODENTS
SMALL INTESTINE
SOMATIC CELLS
THIOLS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ULCERS
VERTEBRATES
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Beschreibung
Zusammenfassung:The authors seek to establish the role of central and peripheral opiate receptors in the antiulcerative action of Dalargin. Rats were used in the experiments. A separate experiment was undertaken to study the passage of Dalargin through the blood-brain barrier. For this, the rats were injected with /sup 3/H-D-Ala/sup 2/, D-leu/sup 5/-enkephalin (/sup 3/H-DADL). The suppression of /sup 3/H-DADL binding in medullar by peripherally injected Dalargin is shown.
ISSN:0007-4888
1573-8221
DOI:10.1007/BF00842476