ATPase activity of cardiac microsomes, regulation of calcium transport in them, and calmodulin levels in experimental myocardial infarction

The aim of this investigation was to continue the study of the integral system: phosphorylation of phospholamban - Ca-activated ATPase of sarcoplasmic reticum (SR) - calmodulin (CaM) - Ca/sup 2 +/ transport in SR in experimental infarction. Experiments were carried out on mongrel dogs weighing 15-18...

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Veröffentlicht in:	Bull. Exp. Biol. Med. (Engl. Transl.); (United States) 1985-02, Vol.99 (2), p.174-176
Hauptverfasser:	Antipenko, A. E., Sviderskaya, E. V., Lyzlova, S. N.
Format:	Artikel
Sprache:	eng
Schlagworte:	ACID ANHYDRASES ALKALINE EARTH ISOTOPES ALKALINE EARTH METAL COMPOUNDS ANIMALS ATP-ASE BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES BIOLOGICAL EFFECTS BODY CALCIUM 45 CALCIUM COMPOUNDS CALCIUM ISOTOPES CARDIOVASCULAR DISEASES CARDIOVASCULAR SYSTEM CELL CONSTITUENTS CHEMICAL REACTIONS DAYS LIVING RADIOISOTOPES DISEASES DOGS ENZYMES EVEN-ODD NUCLEI HEART HYDROLASES INTERMEDIATE MASS NUCLEI ION EXCHANGE ISOTOPE APPLICATIONS ISOTOPES LABELLED COMPOUNDS LIGHT NUCLEI MAMMALS METABOLIC ACTIVATION MICROSOMES MUSCLES MYOCARDIAL INFARCTION MYOCARDIUM NUCLEI ODD-EVEN NUCLEI ORGANIC COMPOUNDS ORGANOIDS ORGANS PHOSPHOHYDROLASES PHOSPHORUS 33 PHOSPHORUS ISOTOPES PHOSPHORYLATION PROTEINS RADIOISOTOPES SARCOPLASMIC RETICULUM TRACER TECHNIQUES VERTEBRATES 550501 > Metabolism-- Tracer Techniques
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Beschreibung
Zusammenfassung:	The aim of this investigation was to continue the study of the integral system: phosphorylation of phospholamban - Ca-activated ATPase of sarcoplasmic reticum (SR) - calmodulin (CaM) - Ca/sup 2 +/ transport in SR in experimental infarction. Experiments were carried out on mongrel dogs weighing 15-18 kg. The reaction was started by addition of 10 microM Ca/sup 2 +/ containing 0.05 microCi of /sup 45/Ca, Ca-activated ATPase activity in the microsomes was estimated as the quantity of /sup 33/P formed in the medium. It is noted that the disturbance of cAMP- and CaM-dependent regulation of Ca/sup 2 +/ transport in SR discovered in myocardial infarction may be one of the decisive factors in the development of irreversible damage to cardiomyocytes.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/BF00798660