Porphyrins. 21. Synthesis and reactivities of 13,17-disubstituted derivatives of 13,17-desethyletioporphyrin III

A method was developed for the preparation, from hemin, of a porphyrin with hydroxypropyl substituents in the 13 and 17 positions of the macroring and a number of its derivatives. The UV and visible spectra of solutions of the compounds in chloroform were recorded with an SF-18 spectrophotometer. The IR spectra of KBr pellets of the compounds were obtained with a Perkin-Elmer 398 spectrometer. The PMR spectra of solutions in CDCl/sub 3/ (with the addition of 5% d/sub 5/-pyridine in the case of the zinc complexes) were recorded with Bruker WM-360 and WM-250 spectrometers with tetramethylsilane (TMS) as the internal standard. The mass spectra were recorded with a Varian MAT-311 spectrometer.