Further support for changes in chloroquine disposition and metabolism between a low and a high dose

The kinetics of chloroquine and its major metabolite desethylchloroquine were studied in patients with rheumatoid disease after single oral doses of chloroquine phosphate corresponding to 150 and 300 mg chloroquine base. The findings strengthen the previous finding that the disposition of chloroquin...

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Veröffentlicht in:	European journal of clinical pharmacology 1985-01, Vol.28 (6), p.721-722
Hauptverfasser:	FRISK-HOLMBERG, M, BERGQVIST, Y, TERMOND, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Arthritis, Rheumatoid - metabolism Biological and medical sciences Chloroquine - administration & dosage Chloroquine - analogs & derivatives Chloroquine - metabolism Creatinine - metabolism Dose-Response Relationship, Drug Female Half-Life Humans Kinetics Medical sciences Metabolic Clearance Rate Middle Aged Pharmacology. Drug treatments
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Beschreibung
Zusammenfassung:	The kinetics of chloroquine and its major metabolite desethylchloroquine were studied in patients with rheumatoid disease after single oral doses of chloroquine phosphate corresponding to 150 and 300 mg chloroquine base. The findings strengthen the previous finding that the disposition of chloroquine involves rate limiting steps.
ISSN:	0031-6970 1432-1041
DOI:	10.1007/BF00607924