Possible involvement of 5-hydroxytryptamine and cyclic-AMP in tolerance to tremorine analgesia in mice
The phenomenon of tolerance to the analgesic action of tremorine in mice was studied by the hot-plate and tail-clip methods. Reduction in 5-HT levels in brain by parachlorophenylalamine pretreatment decreased the ED50 of tremorine analgesia in tremorine tolerant mice. 5-Hydroxyptophan, L-Dopa or alp...
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| Veröffentlicht in: | Psychopharmacology 1977-01, Vol.52 (2), p.213-216 |
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| creator | Naik, S R Amladi, S R Sheth, U K |
| description | The phenomenon of tolerance to the analgesic action of tremorine in mice was studied by the hot-plate and tail-clip methods. Reduction in 5-HT levels in brain by parachlorophenylalamine pretreatment decreased the ED50 of tremorine analgesia in tremorine tolerant mice. 5-Hydroxyptophan, L-Dopa or alpha-methyl-para-tyrosine did not influence the analgesic response to tremorine in tremorine tolerant animals. However, theophylline was found to enhance the tolerance to tremorine analgesia. Brain 5-HT and cAMP are probably involved in tremorine tolerance, whereas neither noradrenaline nor dopamine is involved in the phenomenon. |
| doi_str_mv | 10.1007/BF00439113 |
| format | Article |
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Reduction in 5-HT levels in brain by parachlorophenylalamine pretreatment decreased the ED50 of tremorine analgesia in tremorine tolerant mice. 5-Hydroxyptophan, L-Dopa or alpha-methyl-para-tyrosine did not influence the analgesic response to tremorine in tremorine tolerant animals. However, theophylline was found to enhance the tolerance to tremorine analgesia. 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Reduction in 5-HT levels in brain by parachlorophenylalamine pretreatment decreased the ED50 of tremorine analgesia in tremorine tolerant mice. 5-Hydroxyptophan, L-Dopa or alpha-methyl-para-tyrosine did not influence the analgesic response to tremorine in tremorine tolerant animals. However, theophylline was found to enhance the tolerance to tremorine analgesia. Brain 5-HT and cAMP are probably involved in tremorine tolerance, whereas neither noradrenaline nor dopamine is involved in the phenomenon.</description><subject>5-Hydroxytryptophan - pharmacology</subject><subject>Analgesics</subject><subject>Animals</subject><subject>Cyclic AMP - physiology</subject><subject>Drug Interactions</subject><subject>Drug Tolerance</subject><subject>Fenclonine - pharmacology</subject><subject>Levodopa - pharmacology</subject><subject>Male</subject><subject>Methyltyrosines - pharmacology</subject><subject>Mice</subject><subject>Serotonin - physiology</subject><subject>Theophylline - pharmacology</subject><subject>Time Factors</subject><subject>Tremorine - pharmacology</subject><issn>0033-3158</issn><issn>1432-2072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkD1PwzAQhi3EVygszAyekQx2Ls7HWCoKSEV0gDmynTMY5aNyQtX8e1yC1Fvuhuc96X0IuRb8TnCe3T8sOU-gEAKOSCQSiFnMs_iYRJwDMBAyPycXff_NwyR5ckZORZEClxGx667vna6Runbb1VtssB1oZ6lkX2Plu904-HEzqMa1SFVbUTOa2hk2f12HBB26Gr1qDYaLDh6bzk-gqj-xd2rPNM7gJTmxqu7x6n_PyMfy8X3xzFZvTy-L-YqZOBcDM0mmoUplyjWA1IVMdIopN1Zklc2zKi4sZtIIC9aCioU1Ruhchu4hpYscZuR2-mt86OXRlhvvGuXHUvByr6o8qArwzQRvfnSD1QH9cwO_fG1kdQ</recordid><startdate>19770101</startdate><enddate>19770101</enddate><creator>Naik, S R</creator><creator>Amladi, S R</creator><creator>Sheth, U K</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19770101</creationdate><title>Possible involvement of 5-hydroxytryptamine and cyclic-AMP in tolerance to tremorine analgesia in mice</title><author>Naik, S R ; Amladi, S R ; Sheth, U K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c281t-c47b3d6560b335b954b6e60cf17df87d29fe75c1f3ff3a21fcc1b850433d6b983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>5-Hydroxytryptophan - pharmacology</topic><topic>Analgesics</topic><topic>Animals</topic><topic>Cyclic AMP - physiology</topic><topic>Drug Interactions</topic><topic>Drug Tolerance</topic><topic>Fenclonine - pharmacology</topic><topic>Levodopa - pharmacology</topic><topic>Male</topic><topic>Methyltyrosines - pharmacology</topic><topic>Mice</topic><topic>Serotonin - physiology</topic><topic>Theophylline - pharmacology</topic><topic>Time Factors</topic><topic>Tremorine - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Naik, S R</creatorcontrib><creatorcontrib>Amladi, S R</creatorcontrib><creatorcontrib>Sheth, U K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Psychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Naik, S R</au><au>Amladi, S R</au><au>Sheth, U K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Possible involvement of 5-hydroxytryptamine and cyclic-AMP in tolerance to tremorine analgesia in mice</atitle><jtitle>Psychopharmacology</jtitle><addtitle>Psychopharmacology (Berl)</addtitle><date>1977-01-01</date><risdate>1977</risdate><volume>52</volume><issue>2</issue><spage>213</spage><epage>216</epage><pages>213-216</pages><issn>0033-3158</issn><eissn>1432-2072</eissn><abstract>The phenomenon of tolerance to the analgesic action of tremorine in mice was studied by the hot-plate and tail-clip methods. 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| ispartof | Psychopharmacology, 1977-01, Vol.52 (2), p.213-216 |
| issn | 0033-3158 1432-2072 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | 5-Hydroxytryptophan - pharmacology Analgesics Animals Cyclic AMP - physiology Drug Interactions Drug Tolerance Fenclonine - pharmacology Levodopa - pharmacology Male Methyltyrosines - pharmacology Mice Serotonin - physiology Theophylline - pharmacology Time Factors Tremorine - pharmacology |
| title | Possible involvement of 5-hydroxytryptamine and cyclic-AMP in tolerance to tremorine analgesia in mice |
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