Possible involvement of 5-hydroxytryptamine and cyclic-AMP in tolerance to tremorine analgesia in mice

Possible involvement of 5-hydroxytryptamine and cyclic-AMP in tolerance to tremorine analgesia in mice

The phenomenon of tolerance to the analgesic action of tremorine in mice was studied by the hot-plate and tail-clip methods. Reduction in 5-HT levels in brain by parachlorophenylalamine pretreatment decreased the ED50 of tremorine analgesia in tremorine tolerant mice. 5-Hydroxyptophan, L-Dopa or alp...

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Veröffentlicht in:Psychopharmacology 1977-01, Vol.52 (2), p.213-216
Hauptverfasser: Naik, S R, Amladi, S R, Sheth, U K
Format: Artikel
Sprache:eng
Schlagworte:
5-Hydroxytryptophan - pharmacology
Analgesics
Animals
Cyclic AMP - physiology
Drug Interactions
Drug Tolerance
Fenclonine - pharmacology
Levodopa - pharmacology
Male
Methyltyrosines - pharmacology
Mice
Serotonin - physiology
Theophylline - pharmacology
Time Factors
Tremorine - pharmacology
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Zusammenfassung:The phenomenon of tolerance to the analgesic action of tremorine in mice was studied by the hot-plate and tail-clip methods. Reduction in 5-HT levels in brain by parachlorophenylalamine pretreatment decreased the ED50 of tremorine analgesia in tremorine tolerant mice. 5-Hydroxyptophan, L-Dopa or alpha-methyl-para-tyrosine did not influence the analgesic response to tremorine in tremorine tolerant animals. However, theophylline was found to enhance the tolerance to tremorine analgesia. Brain 5-HT and cAMP are probably involved in tremorine tolerance, whereas neither noradrenaline nor dopamine is involved in the phenomenon.
ISSN:0033-3158
1432-2072
DOI:10.1007/BF00439113