Long-lasting single-dose tolerance to neurologic deficits induced by diazepam

Development of single-dose tolerance to diazepam-induced neurologic deficits was assessed in mice by means of a rotarod test. Diazepam suspended in corn oil was administered orally in doses 5-20 mg/kg. Tolerance was found following a second administration of diazepam 24 h after a first dose. It deca...

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Veröffentlicht in:	Psychopharmacologia 1984-01, Vol.82 (3), p.161-163
Hauptverfasser:	HENAUER, S. A, GALLAHER, E. J, HOLLISTER, L. E
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Ataxia - chemically induced Biological and medical sciences Diazepam - pharmacology Drug Tolerance Drug toxicity and drugs side effects treatment Male Medical sciences Nervous System Diseases - chemically induced Pharmacology. Drug treatments Rats Toxicity: nervous system and muscle
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Zusammenfassung:	Development of single-dose tolerance to diazepam-induced neurologic deficits was assessed in mice by means of a rotarod test. Diazepam suspended in corn oil was administered orally in doses 5-20 mg/kg. Tolerance was found following a second administration of diazepam 24 h after a first dose. It decayed gradually over 4-5 weeks. Hence tolerance persists considerably longer than measurable amounts of diazepam or its metabolites are likely to be present in mice.
ISSN:	0033-3158 1432-2072
DOI:	10.1007/BF00427765