Effect of cannabinoids on the abdominal constriction response in mice: within cannabinoid interactions

Effect of cannabinoids on the abdominal constriction response in mice: within cannabinoid interactions

After oral administration to mice, delta9-tetrahydrocannabinol (THC) and cannabinol (CBN) caused a dose-dependent suppression of the abdominal constriction response to formic acid. Cannabinol was 50 times less active than THC and cannabidiol (CBD) was without effect. The effects of THC and CBN were...

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Veröffentlicht in:Psychopharmacologia 1976, Vol.46 (1), p.83-85
Hauptverfasser: Welburn, P J, Starmer, G A, Chesher, G B, Jackson, D M
Format: Artikel
Sprache:eng
Schlagworte:
Abdomen - drug effects
Analgesia
Animals
Cannabidiol - pharmacology
Dose-Response Relationship, Drug
Dronabinol - pharmacology
Drug Interactions
Female
Formates - antagonists & inhibitors
Mice
Pain - chemically induced
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Zusammenfassung:After oral administration to mice, delta9-tetrahydrocannabinol (THC) and cannabinol (CBN) caused a dose-dependent suppression of the abdominal constriction response to formic acid. Cannabinol was 50 times less active than THC and cannabidiol (CBD) was without effect. The effects of THC and CBN were additive. CBD antagonised the antinociceptive effects of both THC and CBN in a dose-dependent manner.
ISSN:0033-3158
1432-2072
DOI:10.1007/BF00421553