A double-blind short-term trial of guanethidine 3% and adrenaline 0.5% combined in one eye drop

A double-blind short-term trial of guanethidine 3% and adrenaline 0.5% combined in one eye drop

A double-blind short-term trial was done to test the effect of guanethidine 3% - adrenaline 0.5% (G-A) in a combined eye drop in 18 patients with open-angle glaucoma and one patient with narrow-angle glaucoma. In 9 of the 19 patients we expected an IOP lowering agent. There was one false-negative re...

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Veröffentlicht in:Albrecht von Graefes Archiv f r Klinische und Experimentelle Ophthalmologie 1977-07, Vol.203 (1), p.73-80
Hauptverfasser: Hoyng, F J, Dake, C L, Greve, E L
Format: Artikel
Sprache:eng
Schlagworte:
Clinical Trials as Topic
Drug Combinations
Epinephrine - administration & dosage
Epinephrine - therapeutic use
False Negative Reactions
Glaucoma - drug therapy
Glaucoma - physiopathology
Guanethidine - administration & dosage
Guanethidine - therapeutic use
Humans
Intraocular Pressure - drug effects
Ophthalmic Solutions
Time Factors
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Zusammenfassung:A double-blind short-term trial was done to test the effect of guanethidine 3% - adrenaline 0.5% (G-A) in a combined eye drop in 18 patients with open-angle glaucoma and one patient with narrow-angle glaucoma. In 9 of the 19 patients we expected an IOP lowering agent. There was one false-negative result. The mean fall in IOP due to G-A was 10.1 mm Hg (range 3 to 23) and 8.7 mm Hg (range-1 to 26) 6 and 8 h after application respectively. There was no effect on IOP in the 9 eyes that received the placebo.
ISSN:0065-6100
1435-702X
DOI:10.1007/BF00410049