Parathion-provoked lethality in rats is reduced by diethyldithiocarbamate

Parathion-provoked lethality in rats is reduced by diethyldithiocarbamate

Intoxication of male rats with 5 mg/kg parathion reduces survival to 15%. Diethyldithiocarbamate (DDC), known to inhibit mixed-function oxidase activity, has no effect on survival rate when this compound is used in a dosage of 300 mg/kg 45 min before or 10 min after parathion intoxication. However,...

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Veröffentlicht in:Archives of toxicology 1985-06, Vol.57 (2), p.144-145
Hauptverfasser: Homann, J, Schneider, S, Matthes, K.J
Format: Artikel
Sprache:eng
Schlagworte:
Animals
carbamates
Ditiocarb - pharmacology
enzyme activity
Lethal Dose 50
lethality
Male
parathion
Parathion - antagonists & inhibitors
Parathion - toxicity
Phenobarbital - pharmacology
Rats
Thiocarbamates - pharmacology
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Zusammenfassung:Intoxication of male rats with 5 mg/kg parathion reduces survival to 15%. Diethyldithiocarbamate (DDC), known to inhibit mixed-function oxidase activity, has no effect on survival rate when this compound is used in a dosage of 300 mg/kg 45 min before or 10 min after parathion intoxication. However, when DDC and parathion are administered simultaneously, the rate of survival rises to 53%.
ISSN:0340-5761
1432-0738
DOI:10.1007/BF00343127