Metabolism and mutagenicity of aromatic amines by human fetal liver

Metabolism and mutagenicity of aromatic amines by human fetal liver

Human fetal liver microsomes were found to metabolize the carcinogen 2-acetylaminoflurene (AAF), the major metabolite being the deacetylated product 2-aminofluorene (AF). On the other hand, N-hydroxy-2-acetylaminofluorene (N-OH-AAF), a proximate carcinogenic metabolite, could not be detected. The hu...

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Veröffentlicht in:Archives of toxicology 1985-06, Vol.57 (2), p.136-138
Hauptverfasser: AUNE, T, HAUGEN, A, DYBING, E
Format: Artikel
Sprache:eng
Schlagworte:
2-Acetylaminofluorene - metabolism
2-Acetylaminofluorene - toxicity
Amines - metabolism
Biological and medical sciences
Biotransformation
Chemical mutagenesis
Female
Fetus - metabolism
Gestational Age
Humans
Medical sciences
Microsomes, Liver - metabolism
Mutagenicity Tests
Mutagens
Pregnancy
Toxicology
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Beschreibung
Zusammenfassung:Human fetal liver microsomes were found to metabolize the carcinogen 2-acetylaminoflurene (AAF), the major metabolite being the deacetylated product 2-aminofluorene (AF). On the other hand, N-hydroxy-2-acetylaminofluorene (N-OH-AAF), a proximate carcinogenic metabolite, could not be detected. The human fetal liver samples converted AF and N-OH-AAF, but not AAF, to products mutagenic for S. typhimurium TA 98.
ISSN:0340-5761
1432-0738
DOI:10.1007/BF00343124