Outcome of bone marrow transplantation in patients with extramedullary involvement of acute leukemia

Infiltration of extrahemopoietic tissue with leukemic cells was evaluated as a prognostic indicator in 18 patients with acute leukemia undergoing bone marrow transplantation. When compared to 107 patients who did not have extramedullary leukemia at any time prior to marrow grafting, the patients wit...

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Veröffentlicht in:	Blut 1984-02, Vol.48 (2), p.75-79
Hauptverfasser:	SPRUCE, W. E, FORMAN, S. J, KRANCE, R. A, FARBSTEIN, M. J, WOLF, J. L, SCOTT, E. P, NADEMANEE, A. P, FAHEY, J. L, HENKE, M, BLUME, K. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adolescent Adult Biological and medical sciences Bone Marrow Transplantation Child Child, Preschool Hematologic and hematopoietic diseases Humans Leukemia - therapy Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences
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Zusammenfassung:	Infiltration of extrahemopoietic tissue with leukemic cells was evaluated as a prognostic indicator in 18 patients with acute leukemia undergoing bone marrow transplantation. When compared to 107 patients who did not have extramedullary leukemia at any time prior to marrow grafting, the patients with leukemic invasion into organs outside the hemopoietic system had a significant increase of leukemic recurrence and a significant decrease in survival after marrow transplantation. Extramedullary leukemia may be a negative prognostic indicator for bone marrow transplantation candidates.
ISSN:	0006-5242 1432-0584
DOI:	10.1007/BF00320033