Impaired protein synthesis in leukemic hairy cells induced by splenectomy

A case of hairy-cell leukemia in which protein synthesis by the leukemic hairy cells could be followed-up before and after splenectomy is presented. After splenectomy a remarkable reduction of initially enhanced protein synthesis was found. This observation supports the view that the splenic microen...

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Veröffentlicht in:	Blut 1983-11, Vol.47 (5), p.307-310
Hauptverfasser:	EMMERICH(B.), PICHLMEIER, R, MAUBACH, P, RASTETTER, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Female Hematologic and hematopoietic diseases Humans Leukemia, Hairy Cell - metabolism Leukemia, Hairy Cell - surgery Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Middle Aged Mitochondria - metabolism Neoplasm Proteins - biosynthesis Splenectomy
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Zusammenfassung:	A case of hairy-cell leukemia in which protein synthesis by the leukemic hairy cells could be followed-up before and after splenectomy is presented. After splenectomy a remarkable reduction of initially enhanced protein synthesis was found. This observation supports the view that the splenic microenvironment has an important influence on the proliferative activity of hairy cells.
ISSN:	0006-5242 1432-0584
DOI:	10.1007/BF00319900