Myopathy with ragged red fibres following renal transplantation : possible role of cyclosporin-induced hypomagnesaemia

A 65-year-old man developed a painless proximal myopathy 7 years after commencing cyclosporin therapy following a successful cadaveric renal transplant. Muscle histology showed ragged red fibres and biochemical studies suggested mitochondrial dysfunction. The possible pathogenesis of this mitochondr...

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Veröffentlicht in:	Acta neuropathologica 1994-08, Vol.88 (2), p.189-192
Hauptverfasser:	LARNER, A. J, STURMAN, S. G, HAWKINS, J. B, ANDERSON, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biological and medical sciences Cyclosporine - adverse effects Drug toxicity and drugs side effects treatment Humans Kidney Transplantation Magnesium Deficiency - chemically induced Magnesium Deficiency - pathology Male Medical sciences Mitochondria, Muscle - physiology Mitochondria, Muscle - ultrastructure Muscle Fibers, Skeletal - ultrastructure Muscular Diseases - etiology Muscular Diseases - pathology Pharmacology. Drug treatments Postoperative Complications - pathology Toxicity: nervous system and muscle
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Beschreibung
Zusammenfassung:	A 65-year-old man developed a painless proximal myopathy 7 years after commencing cyclosporin therapy following a successful cadaveric renal transplant. Muscle histology showed ragged red fibres and biochemical studies suggested mitochondrial dysfunction. The possible pathogenesis of this mitochondrial myopathy, particularly its relationship to cyclosporin-induced hypomagnesaemia, is discussed.
ISSN:	0001-6322 1432-0533
DOI:	10.1007/BF00294514