The clinical comparison of skeletal imaging agents

The clinical comparison of skeletal imaging agents

99-MTc-methylene diophosphonate from two manufacturers was compared with 99mTc-ethane hydroxy diphosphonate in a randomised trial to assess the relative blood clearances and the subsequent image quality. The 99mTc-methylene diphosphonate preparations were found to be superior with respect to both bl...

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Veröffentlicht in:European Journal of Nuclear Medicine 1980-06, Vol.5 (3), p.257-260
Hauptverfasser: Adams, F G, Horton, P W, Stenhouse, G
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Bone and Bones - diagnostic imaging
Clinical Trials as Topic
Diphosphonates
Etidronic Acid
Female
Humans
Male
Middle Aged
Radionuclide Imaging
Random Allocation
Technetium
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Zusammenfassung:99-MTc-methylene diophosphonate from two manufacturers was compared with 99mTc-ethane hydroxy diphosphonate in a randomised trial to assess the relative blood clearances and the subsequent image quality. The 99mTc-methylene diphosphonate preparations were found to be superior with respect to both blood clearance and subjectively assessed image quality, particularly when the interval between injection and scanning was three hours. Bone/soft tissue ratios did not mirror the highly significant qualitative comparisons of image quality.
ISSN:0340-6997
1619-7089
DOI:10.1007/BF00271908