The effect of synovectomy on the articular cartilage of the knee joint in rabbits

Subtotal synovectomy was performed on the right knee joints of 20 immature and 20 mature rabbits, and articular cartilage from the femoral and tibial condyles and the patellae was examined at 1, 3, 5 and 12 weeks after operation. Specimens from the unoperated left knees provided the controls. Each specimen was examined macroscopically and with histological (H-E stain) and histochemical (safranin-O stain) techniques for abnormalities in structure, cell population, stain intensity and distribution. The femoral articular cartilage was most affected by synovectomy. The tibial articular cartilage was only moderately affected and the patellar articular cartilage was even less affected. The histochemical changes were transient and reversible, being more severe and prolonged in the mature animals. No changes in either group were noted on gross inspection or in the H-E stained sections.