Kinetics of 2,4,6-trichlorophenol in different organs of the rat

The concentration of 2,4,6-trichlorophenol was measured in the blood and various other tissues of the rat after IP administration of the compound at 25 mg per kg body weight. The highest concentration, 329 +/- 117 nmol X g-1, was found in the kidney. Half-times were between 1.4 and 1.8 h in the bloo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Archives of toxicology 1986-05, Vol.59 (1), p.41-44
Hauptverfasser:	PEKARI, K, BOUDENE, C, AITIO, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Chlorophenols - blood Chlorophenols - metabolism Chromatography, Gas Female Glucuronates - metabolism Kinetics Medical sciences Organ Size Organ Specificity Pesticides, fertilizers and other agrochemicals toxicology Rats Rats, Inbred Strains Tissue Distribution Toxicology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The concentration of 2,4,6-trichlorophenol was measured in the blood and various other tissues of the rat after IP administration of the compound at 25 mg per kg body weight. The highest concentration, 329 +/- 117 nmol X g-1, was found in the kidney. Half-times were between 1.4 and 1.8 h in the blood, brain, fat, kidney, liver and muscle. The extent of conjugation of 2,4,6-trichlorophenol was also investigated by measuring total and free chlorophenol in the blood.
ISSN:	0340-5761 1432-0738
DOI:	10.1007/BF00263956