The cytotoxicity of T-2 toxin and related 12,13-epoxytrichothecenes to adriamycin-sensitive and -resistant P388 leukemia cells

The cytotoxicity of T-2 toxin and related trichothecenes was studied in Adriamycin-sensitive and -resistant P388 leukemia cells in vitro. The structure-activity relationship indicated that a free hydroxyl in the C-3 position contributed to the activity. Free hydroxyls at the 4, 8, and 15 positions i...

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Veröffentlicht in:Cancer chemotherapy and pharmacology 1989-10, Vol.24 (4), p.264-267
Hauptverfasser: RAMU, A, YAGEN, B, RAMU, N
Format: Artikel
Sprache:eng
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Zusammenfassung:The cytotoxicity of T-2 toxin and related trichothecenes was studied in Adriamycin-sensitive and -resistant P388 leukemia cells in vitro. The structure-activity relationship indicated that a free hydroxyl in the C-3 position contributed to the activity. Free hydroxyls at the 4, 8, and 15 positions interfered with the activity, and their estrification resulted in improved cytotoxicity. The cytotoxic activity of these trichothecenes did not seem to be related to their degree of lipophilicity. Adriamycin-resistant P388 cells were cross-resistant to the trichothecenes, and this resistance could be circumvented by verapamil.
ISSN:0344-5704
1432-0843
DOI:10.1007/BF00257631