Potentiation of cis-diamminedichloroplatinum nephrotoxicity by amikacin in rats

The nephrotoxic interaction between cis-diamminedichloroplatinum (CDDP) and amikacin (AMI) was studied in rats. Following a single dose of CDDP (5 mg/kg i.v.), AMI (60 mg/kg s.c.) was given for 14 days. When given alone CDDP caused a 40% fall in the glomerular filtration rate (GFR), whereas AMI alon...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 1988-01, Vol.22 (2), p.178-180
Hauptverfasser:	JONGEJAN, H. T. M, PROVOOST, A. P, MOLENAAR, J. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Amikacin - toxicity Animals Biological and medical sciences Cisplatin - toxicity Drug Synergism Drug toxicity and drugs side effects treatment Glomerular Filtration Rate - drug effects Kidney - blood supply Kidney - drug effects Male Medical sciences Pharmacology. Drug treatments Rats Rats, Inbred Strains Regional Blood Flow - drug effects Toxicity: urogenital system
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Zusammenfassung:	The nephrotoxic interaction between cis-diamminedichloroplatinum (CDDP) and amikacin (AMI) was studied in rats. Following a single dose of CDDP (5 mg/kg i.v.), AMI (60 mg/kg s.c.) was given for 14 days. When given alone CDDP caused a 40% fall in the glomerular filtration rate (GFR), whereas AMI alone had no effect on GFR. This nonnephrotoxic course of AMI potentiated the CDDP-induced fall in GFR. Only a limited recovery of renal function was observed during a 15-week follow-up period.
ISSN:	0344-5704 1432-0843
DOI:	10.1007/BF00257319