Phase II trial of PCNU in breast carcinoma

The Eastern Cooperative Oncology Group undertook a limited institution phase II study of PCNU in advanced, metastatic breast cancer. The study was limited to patients treated with 1 to 2 prior chemotherapy regimens. Accrual goals were 30 patients but the study was terminated after 10 patients had no...

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Veröffentlicht in:	Investigational new drugs 1989-07, Vol.7 (2-3), p.239-241
Hauptverfasser:	RUBINS, J. M, TAYLOR, S. G. IV
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic agents Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Biological and medical sciences Breast Neoplasms - drug therapy Chemotherapy Drug Evaluation Female Humans Medical sciences Middle Aged Neoplasm Metastasis Nitrosourea Compounds - adverse effects Nitrosourea Compounds - therapeutic use Pharmacology. Drug treatments
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Beschreibung
Zusammenfassung:	The Eastern Cooperative Oncology Group undertook a limited institution phase II study of PCNU in advanced, metastatic breast cancer. The study was limited to patients treated with 1 to 2 prior chemotherapy regimens. Accrual goals were 30 patients but the study was terminated after 10 patients had no response, with a rapid time to progression of 4 weeks, despite considerable hematologic toxicity. Based on this experience and negative results in two prior studies in more heavily pretreated patients, we conclude PCNU is inactive in breast cancer.
ISSN:	0167-6997 1573-0646
DOI:	10.1007/BF00170866