Kinetic Determination of Furazolidone and Furaltadone Based on Alkaline Hydrolysis Reaction

A simple and rapid kinetic method for the determination of furazolidone or furaltadone is reported. It is based on the measurement of the rate of their alkaline hydrolysis reaction. Kinetic data are recorded spectrophotometrically at 425 or 430 nm, the maximum absorption wavelengths of the respective hydrolysis products. The calibration plots are linear in the range 1-20 μg/ml and the detection limits are 0.17 and 0.19 μg/ml for furazolidone and furaltadone, respectively. The precision of the method, expressed as the relative standard deviation, is 1.2% for 9.0 μg/ml furazolidone and 1.4% for 9.0 μg/ml furaltadone. Good recoveries have been obtained in applying the method to the analysis of furazolidone or furaltadone in pharmaceutical preparations and feed.