Oral Treosulfan as Second-Line Treatment in Platinum-Resistant Ovarian Cancer: A Phase II Study

Objective.To evaluate the effect of oral treosulfan in patients with platinum-resistant ovarian cancer. Methods.A phase II trial of oral treosulfan 500 mg per day in 30 females with platinum resistant ovarian cancer. All patients had measurable or evaluable disease. Results.The treatment was well tolerated. One patient (3%) achieved a partial response lasting 12+ months. Seven patients had stable disease for 5.3 months (median) range 4.4–7.5 months. Median time to progression was 11.5 weeks (95% C.L. 11–12 weeks). Median survival was 31 weeks (95% C.L. 30–35 weeks). Conclusion.Oral treosulfan in the present schedule is not recommended in platinum resistant ovarian cancer.