The Human Glutamate Receptor δ2 Gene (GRID2) Maps to Chromosome 4q22

We isolated the human glutamate receptor δ2 (GRID2) gene, which has 97.0% identity in amino acid sequence to the mouse glutamate receptor δ2 (Grid2) gene. We subsequently mapped this gene to human chromosome 4q22 by radiation hybrid mapping and by hybridization to two overlapping human yeast artific...

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Veröffentlicht in:	Genomics (San Diego, Calif.) Calif.), 1998-01, Vol.47 (1), p.143-145
Hauptverfasser:	Hu, Wei, Zuo, Jian, De Jager, Philip L., Heintz, Nathaniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Classical genetics, quantitative genetics, hybrids Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Human
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Zusammenfassung:	We isolated the human glutamate receptor δ2 (GRID2) gene, which has 97.0% identity in amino acid sequence to the mouse glutamate receptor δ2 (Grid2) gene. We subsequently mapped this gene to human chromosome 4q22 by radiation hybrid mapping and by hybridization to two overlapping human yeast artificial chromosomes that are located in 4q22. TheGrid2gene, which is mutated in lurcher (Lc) mice, maps to mouse chromosome 6. Thus, the mapping of theGRID2gene to human chromosome 4q22 confirms and refines a region of synteny between mouse and human genomes.
ISSN:	0888-7543 1089-8646
DOI:	10.1006/geno.1997.5108