Cloning of the HumanSIX1Gene and Its Assignment to Chromosome 14

Cloning of the HumanSIX1Gene and Its Assignment to Chromosome 14

The recently described murine homeobox genes,Six1andSix2,which are expressed during development in limb tendons, have also been shown to be expressed in skeletal and smooth muscle, respectively. We have cloned and sequenced a humanSIX1cDNA and shown by Northern blotting that it is expressed in adult...

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Veröffentlicht in:Genomics (San Diego, Calif.) Calif.), 1996-04, Vol.33 (1), p.140-142
Hauptverfasser: Boucher, Catherine A., Carey, Nessa, Edwards, Yvonne H., Siciliano, Michael J., Johnson, Keith J.
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Sprache:eng
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Zusammenfassung:The recently described murine homeobox genes,Six1andSix2,which are expressed during development in limb tendons, have also been shown to be expressed in skeletal and smooth muscle, respectively. We have cloned and sequenced a humanSIX1cDNA and shown by Northern blotting that it is expressed in adult skeletal muscle. The cDNA sequence and predicted protein sequence ofSIX1andSix1are highly homologous, with 98% similarity over the entire predicted amino acid sequence.SIX1was mapped to human chromosome 14 using a rodent/human somatic cell hybrid panel.
ISSN:0888-7543
1089-8646
DOI:10.1006/geno.1996.0172