The Toxic Milk Mutation,tx,Which Results in a Condition Resembling Wilson Disease in Humans, Is Linked to Mouse Chromosome 8

Litters produced by females homozygous for the toxic milk mutation, tx/tx, display a syndrome that includes poor growth, hypopigmentation, tremors, and death before 2 weeks of age. These features, consistent with copper deficiency, are attributed to failure in fetal hepatic copper accumulation. Here...

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Veröffentlicht in:	Genomics 1995-09, Vol.29 (2), p.551-552
Hauptverfasser:	Rauch, Harold, Wells, April J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences BIOLOGY AND MEDICINE, BASIC STUDIES Chromosome Mapping CHROMOSOMES Classical genetics, quantitative genetics, hybrids COPPER Copper - metabolism Crosses, Genetic Female Fundamental and applied biological sciences. Psychology GENE MUTATIONS GENES Genetic Linkage GENETIC MAPPING Genetic Markers Genetics of eukaryotes. Biological and molecular evolution Hepatolenticular Degeneration - genetics HEREDITARY DISEASES HYBRIDIZATION Male METABOLISM Metal Metabolism, Inborn Errors - genetics MICE Mice, Mutant Strains Milk - chemistry Mutation Recombination, Genetic Vertebrata
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Zusammenfassung:	Litters produced by females homozygous for the toxic milk mutation, tx/tx, display a syndrome that includes poor growth, hypopigmentation, tremors, and death before 2 weeks of age. These features, consistent with copper deficiency, are attributed to failure in fetal hepatic copper accumulation. Here we report the chromosomal linkage of this mutation. 5 refs., 1 tab.
ISSN:	0888-7543 1089-8646
DOI:	10.1006/geno.1995.9968