Soluble Tumor Necrosis Factor Receptors are Present in Human Vitreous and Shed by Retinal Pigment Epithelial Cells

Tumor necrosis factor-alpha (TNF) has been implicated in the pathogenesis of several retinal diseases. Soluble forms of the TNF receptors, p55 (55 kDa) and p75 (75 kDa), have recently been identified in biological fluids and may regulate TNF activity. The potential biological significance of these r...

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Veröffentlicht in:	Experimental eye research 1996-09, Vol.63 (3), p.311-317
Hauptverfasser:	SIPPY, BRIAN D., HOFMAN, FLORENCE M., WRIGHT, ALBION D., HE, SHIKUN, RYAN, STEPHEN J., HINTON, DAVID R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Biological and medical sciences Cells, Cultured Culture Media, Conditioned - analysis Enzyme-Linked Immunosorbent Assay Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Humans In Vitro Techniques Naphthalenes - pharmacology Pigment Epithelium of Eye - metabolism PKC protein kinase Protein Kinase C - antagonists & inhibitors Protein Kinase C - physiology Receptors, Tumor Necrosis Factor - analysis Receptors, Tumor Necrosis Factor - metabolism RPE soluble cytokine receptor Tetradecanoylphorbol Acetate - pharmacology TNF binding protein Vertebrates: nervous system and sense organs Vitreous Body - metabolism
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Zusammenfassung:	Tumor necrosis factor-alpha (TNF) has been implicated in the pathogenesis of several retinal diseases. Soluble forms of the TNF receptors, p55 (55 kDa) and p75 (75 kDa), have recently been identified in biological fluids and may regulate TNF activity. The potential biological significance of these receptors for the human retina was examined by determining their presence in human vitreous and their release from eye cup explants in which the retina has been removed leaving an intact retinal pigment epithelium (HRPE). Normal human vitreous and conditioned medium from eye-cup HRPE explants demonstrated the presence of soluble p55 and p75. Soluble p55 was significantly more abundant than p75 in all vitreous samples ( P
ISSN:	0014-4835 1096-0007
DOI:	10.1006/exer.1996.0120