EFFECTS OF INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 2 AND AN IGF-TYPE I RECEPTOR-BLOCKING ANTIBODY ON APOPTOSIS IN HUMAN TERATOCARCINOMA CELLS IN VITRO
Human teratocarcinoma cells (Tera-2) deprived of serum undergo programmed cell death which can be counteracted by simultaneous addition of IGF-I or IGF-II. This protective effect of IGFs was specific in the sense that both addition of IGF-binding protein-2, and blocking of the IGF-type I receptor by...
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| Veröffentlicht in: | Cell biology international 2001-08, Vol.25 (8), p.825-828 |
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| container_title | Cell biology international |
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| creator | Granerus, Marika Engström, Wilhelm |
| description | Human teratocarcinoma cells (Tera-2) deprived of serum undergo programmed cell death which can be counteracted by simultaneous addition of IGF-I or IGF-II. This protective effect of IGFs was specific in the sense that both addition of IGF-binding protein-2, and blocking of the IGF-type I receptor by a specific antibody, both resulted in an increased apoptotic rate. |
| doi_str_mv | 10.1006/cbir.2001.0756 |
| format | Article |
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This protective effect of IGFs was specific in the sense that both addition of IGF-binding protein-2, and blocking of the IGF-type I receptor by a specific antibody, both resulted in an increased apoptotic rate.</description><identifier>ISSN: 1065-6995</identifier><identifier>EISSN: 1095-8355</identifier><identifier>DOI: 10.1006/cbir.2001.0756</identifier><identifier>PMID: 11482908</identifier><language>eng</language><publisher>Oxford, UK: Elsevier Ltd</publisher><subject>Antibodies - pharmacology ; apoptosis ; Apoptosis - drug effects ; Cell Count ; Cell Division - drug effects ; Dose-Response Relationship, Drug ; Humans ; IGF-binding protein ; Insulin-Like Growth Factor I - pharmacology ; Insulin-Like Growth Factor II - pharmacology ; Receptor, IGF Type 1 - immunology ; teratocarcinoma ; Teratocarcinoma - pathology ; Teratocarcinoma - prevention & control ; Time Factors ; Tumor Cells, Cultured - cytology ; Tumor Cells, Cultured - drug effects ; type I IGF receptor</subject><ispartof>Cell biology international, 2001-08, Vol.25 (8), p.825-828</ispartof><rights>2001 Academic Press</rights><rights>The Author(s) Journal compilation © 2001 International Federation for Cell Biology</rights><rights>Copyright 2001 Academic Press.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1006%2Fcbir.2001.0756$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1006%2Fcbir.2001.0756$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27907,27908,45557,45558</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11482908$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Granerus, Marika</creatorcontrib><creatorcontrib>Engström, Wilhelm</creatorcontrib><title>EFFECTS OF INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 2 AND AN IGF-TYPE I RECEPTOR-BLOCKING ANTIBODY ON APOPTOSIS IN HUMAN TERATOCARCINOMA CELLS IN VITRO</title><title>Cell biology international</title><addtitle>Cell Biol Int</addtitle><description>Human teratocarcinoma cells (Tera-2) deprived of serum undergo programmed cell death which can be counteracted by simultaneous addition of IGF-I or IGF-II. 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This protective effect of IGFs was specific in the sense that both addition of IGF-binding protein-2, and blocking of the IGF-type I receptor by a specific antibody, both resulted in an increased apoptotic rate.</abstract><cop>Oxford, UK</cop><pub>Elsevier Ltd</pub><pmid>11482908</pmid><doi>10.1006/cbir.2001.0756</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1065-6995 |
| ispartof | Cell biology international, 2001-08, Vol.25 (8), p.825-828 |
| issn | 1065-6995 1095-8355 |
| language | eng |
| recordid | cdi_crossref_primary_10_1006_cbir_2001_0756 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Antibodies - pharmacology apoptosis Apoptosis - drug effects Cell Count Cell Division - drug effects Dose-Response Relationship, Drug Humans IGF-binding protein Insulin-Like Growth Factor I - pharmacology Insulin-Like Growth Factor II - pharmacology Receptor, IGF Type 1 - immunology teratocarcinoma Teratocarcinoma - pathology Teratocarcinoma - prevention & control Time Factors Tumor Cells, Cultured - cytology Tumor Cells, Cultured - drug effects type I IGF receptor |
| title | EFFECTS OF INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 2 AND AN IGF-TYPE I RECEPTOR-BLOCKING ANTIBODY ON APOPTOSIS IN HUMAN TERATOCARCINOMA CELLS IN VITRO |
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