EFFECTS OF INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 2 AND AN IGF-TYPE I RECEPTOR-BLOCKING ANTIBODY ON APOPTOSIS IN HUMAN TERATOCARCINOMA CELLS IN VITRO

EFFECTS OF INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 2 AND AN IGF-TYPE I RECEPTOR-BLOCKING ANTIBODY ON APOPTOSIS IN HUMAN TERATOCARCINOMA CELLS IN VITRO

Human teratocarcinoma cells (Tera-2) deprived of serum undergo programmed cell death which can be counteracted by simultaneous addition of IGF-I or IGF-II. This protective effect of IGFs was specific in the sense that both addition of IGF-binding protein-2, and blocking of the IGF-type I receptor by...

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Veröffentlicht in:Cell biology international 2001-08, Vol.25 (8), p.825-828
Hauptverfasser: Granerus, Marika, Engström, Wilhelm
Format: Artikel
Sprache:eng
Schlagworte:
Antibodies - pharmacology
apoptosis
Apoptosis - drug effects
Cell Count
Cell Division - drug effects
Dose-Response Relationship, Drug
Humans
IGF-binding protein
Insulin-Like Growth Factor I - pharmacology
Insulin-Like Growth Factor II - pharmacology
Receptor, IGF Type 1 - immunology
teratocarcinoma
Teratocarcinoma - pathology
Teratocarcinoma - prevention & control
Time Factors
Tumor Cells, Cultured - cytology
Tumor Cells, Cultured - drug effects
type I IGF receptor
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Zusammenfassung:Human teratocarcinoma cells (Tera-2) deprived of serum undergo programmed cell death which can be counteracted by simultaneous addition of IGF-I or IGF-II. This protective effect of IGFs was specific in the sense that both addition of IGF-binding protein-2, and blocking of the IGF-type I receptor by a specific antibody, both resulted in an increased apoptotic rate.
ISSN:1065-6995
1095-8355
DOI:10.1006/cbir.2001.0756