The Thiazolidinedione Insulin Sensitiser, BRL 49653, Increases the Expression of PPAR-γ and aP2in Adipose Tissue of High-Fat-Fed Rats

The Thiazolidinedione Insulin Sensitiser, BRL 49653, Increases the Expression of PPAR-γ and aP2in Adipose Tissue of High-Fat-Fed Rats

The effects of the thiazolidinedione insulin sensitiser BRL 49653 on plasma leptin concentrations and on epididymal fat OB, PPAR-γ and aP2mRNA expression were examined in high-fat-fed and high-carbohydrate-fed adult Wistar rats. Diets were given for 4 weeks, with BRL 49653 (10μmol/kg/day) administer...

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Veröffentlicht in:Biochemical and biophysical research communications 1996-12, Vol.229 (3), p.752-757
Hauptverfasser: Pearson, S.L., Cawthorne, M.A., Clapham, J.C., Dunmore, S.J., Holmes, S.D., Moore, G.B.T., Smith, S.A., Tadayyon, M.
Format: Artikel
Sprache:eng
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Zusammenfassung:The effects of the thiazolidinedione insulin sensitiser BRL 49653 on plasma leptin concentrations and on epididymal fat OB, PPAR-γ and aP2mRNA expression were examined in high-fat-fed and high-carbohydrate-fed adult Wistar rats. Diets were given for 4 weeks, with BRL 49653 (10μmol/kg/day) administered by oral gavage for the last 4 days. Treatment with BRL 49653 reduced plasma leptin concentrations in high-fat-fed rats from 2.34 ± 0.19 (n=9) to 1.42 ± 0.09 (n=9) ng/ml (p
ISSN:0006-291X
1090-2104
DOI:10.1006/bbrc.1996.1876