Platelet-Derived Growth Factor Is a Potent Stimulator of Expression of Intercellular Adhesion Molecule-1 in Human Arterial Smooth Muscle Cells
The effects of platelet-derived growth factor (PDGF) on the expression of intercellular adhesion molecule-1(ICAM-1) as an indicator of cell activation were investigated in cultured human arterial smooth muscle cells(SMC). PDGF-BB and -AB but not -AA at 2-10 ng/ml stimulated ICAM-1 expression at a su...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1994-04, Vol.200 (1), p.612-618 |
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| creator | Morisaki, N. Takahashi, K. Shiina, R. Zenibayashi, M. Otabe, M. Yoshida, S. Saito, Y. |
| description | The effects of platelet-derived growth factor (PDGF) on the expression of intercellular adhesion molecule-1(ICAM-1) as an indicator of cell activation were investigated in cultured human arterial smooth muscle cells(SMC). PDGF-BB and -AB but not -AA at 2-10 ng/ml stimulated ICAM-1 expression at a subconfluent but not a confluent state in a dose-dependent manner. ICAM-1 expression was induced at 2h, reached a plateau at 4h, and continued for at least 24h after stimulation with PDGF. The maximal stimulatory effect of PDGF-BB at 10 ng/ml was comparable to that by optimal concentrations of other cytokines and inflammatory agents. These data suggested that PDGF was a potent stimulator of ICAM-1. |
| doi_str_mv | 10.1006/bbrc.1994.1492 |
| format | Article |
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PDGF-BB and -AB but not -AA at 2-10 ng/ml stimulated ICAM-1 expression at a subconfluent but not a confluent state in a dose-dependent manner. ICAM-1 expression was induced at 2h, reached a plateau at 4h, and continued for at least 24h after stimulation with PDGF. The maximal stimulatory effect of PDGF-BB at 10 ng/ml was comparable to that by optimal concentrations of other cytokines and inflammatory agents. 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Psychology ; Gene Expression - drug effects ; Humans ; Intercellular Adhesion Molecule-1 ; Interleukin-1 - pharmacology ; Interleukin-4 - pharmacology ; Kinetics ; Lipopolysaccharides - pharmacology ; Molecular and cellular biology ; Muscle, Smooth, Vascular - drug effects ; Muscle, Smooth, Vascular - metabolism ; Phospholipases A - pharmacology ; Platelet-Derived Growth Factor - pharmacology ; Proto-Oncogene Proteins c-sis ; Recombinant Proteins - pharmacology ; Responses to growth factors, tumor promotors, other factors ; Structure-Activity Relationship ; Tetradecanoylphorbol Acetate - pharmacology ; Tumor Necrosis Factor-alpha - pharmacology</subject><ispartof>Biochemical and biophysical research communications, 1994-04, Vol.200 (1), p.612-618</ispartof><rights>1994 Academic Press</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-9be31a4e1b3766ac180d24f694302ab1dc76c792077871391420a55503a3082f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1006/bbrc.1994.1492$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4081997$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7909437$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morisaki, N.</creatorcontrib><creatorcontrib>Takahashi, K.</creatorcontrib><creatorcontrib>Shiina, R.</creatorcontrib><creatorcontrib>Zenibayashi, M.</creatorcontrib><creatorcontrib>Otabe, M.</creatorcontrib><creatorcontrib>Yoshida, S.</creatorcontrib><creatorcontrib>Saito, Y.</creatorcontrib><title>Platelet-Derived Growth Factor Is a Potent Stimulator of Expression of Intercellular Adhesion Molecule-1 in Human Arterial Smooth Muscle Cells</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>The effects of platelet-derived growth factor (PDGF) on the expression of intercellular adhesion molecule-1(ICAM-1) as an indicator of cell activation were investigated in cultured human arterial smooth muscle cells(SMC). PDGF-BB and -AB but not -AA at 2-10 ng/ml stimulated ICAM-1 expression at a subconfluent but not a confluent state in a dose-dependent manner. ICAM-1 expression was induced at 2h, reached a plateau at 4h, and continued for at least 24h after stimulation with PDGF. The maximal stimulatory effect of PDGF-BB at 10 ng/ml was comparable to that by optimal concentrations of other cytokines and inflammatory agents. These data suggested that PDGF was a potent stimulator of ICAM-1.</description><subject>Antigens, CD - biosynthesis</subject><subject>Arteries - drug effects</subject><subject>Arteries - metabolism</subject><subject>Biological and medical sciences</subject><subject>Cell Adhesion Molecules - biosynthesis</subject><subject>Cell physiology</subject><subject>Cells, Cultured</subject><subject>Cytokines - pharmacology</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression - drug effects</subject><subject>Humans</subject><subject>Intercellular Adhesion Molecule-1</subject><subject>Interleukin-1 - pharmacology</subject><subject>Interleukin-4 - pharmacology</subject><subject>Kinetics</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Molecular and cellular biology</subject><subject>Muscle, Smooth, Vascular - drug effects</subject><subject>Muscle, Smooth, Vascular - metabolism</subject><subject>Phospholipases A - pharmacology</subject><subject>Platelet-Derived Growth Factor - pharmacology</subject><subject>Proto-Oncogene Proteins c-sis</subject><subject>Recombinant Proteins - pharmacology</subject><subject>Responses to growth factors, tumor promotors, other factors</subject><subject>Structure-Activity Relationship</subject><subject>Tetradecanoylphorbol Acetate - pharmacology</subject><subject>Tumor Necrosis Factor-alpha - pharmacology</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE9P3DAQxS1UBAvtlVslH3rNdibxJvFxtfxbCQQSVOotcpyJcOXEK9uh7ZfoZ8bprrhxGnne7814HmMXCEsEKL-3rddLlFIsUcj8iC0QJGQ5gvjEFpCILJf485SdhfALAFGU8oSdVBKkKKoF-_doVSRLMbskb16p4zfe_Y4v_Frp6DzfBq74o4s0Rv4UzTAlPLVdz6_-7DyFYNw4v7ZjJK_J2gR4vu5e6L9y7yzpyVKG3Iz8dhrUyNc-oUZZ_jQ4lzbdT0Fb4ptkDp_Zca9soC-Hes5-XF89b26zu4eb7WZ9l2lRiJjJlgpUgrAtqrJUGmvoctGX6SbIVYudrkpdyRyqqq6wkChyUKvVCgpVQJ33xTlb7udq70Lw1Dc7bwbl_zYIzZxrM-fazLk2c67J8HVv2E3tQN07fggy6d8Ougpa2d6rUZvwjgmo06wZq_cYpeNeDfkmaEOjps540rHpnPnoB29ZB5Q9</recordid><startdate>19940415</startdate><enddate>19940415</enddate><creator>Morisaki, N.</creator><creator>Takahashi, K.</creator><creator>Shiina, R.</creator><creator>Zenibayashi, M.</creator><creator>Otabe, M.</creator><creator>Yoshida, S.</creator><creator>Saito, Y.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19940415</creationdate><title>Platelet-Derived Growth Factor Is a Potent Stimulator of Expression of Intercellular Adhesion Molecule-1 in Human Arterial Smooth Muscle Cells</title><author>Morisaki, N. ; Takahashi, K. ; Shiina, R. ; Zenibayashi, M. ; Otabe, M. ; Yoshida, S. ; Saito, Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-9be31a4e1b3766ac180d24f694302ab1dc76c792077871391420a55503a3082f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Antigens, CD - biosynthesis</topic><topic>Arteries - drug effects</topic><topic>Arteries - metabolism</topic><topic>Biological and medical sciences</topic><topic>Cell Adhesion Molecules - biosynthesis</topic><topic>Cell physiology</topic><topic>Cells, Cultured</topic><topic>Cytokines - pharmacology</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression - drug effects</topic><topic>Humans</topic><topic>Intercellular Adhesion Molecule-1</topic><topic>Interleukin-1 - pharmacology</topic><topic>Interleukin-4 - pharmacology</topic><topic>Kinetics</topic><topic>Lipopolysaccharides - pharmacology</topic><topic>Molecular and cellular biology</topic><topic>Muscle, Smooth, Vascular - drug effects</topic><topic>Muscle, Smooth, Vascular - metabolism</topic><topic>Phospholipases A - pharmacology</topic><topic>Platelet-Derived Growth Factor - pharmacology</topic><topic>Proto-Oncogene Proteins c-sis</topic><topic>Recombinant Proteins - pharmacology</topic><topic>Responses to growth factors, tumor promotors, other factors</topic><topic>Structure-Activity Relationship</topic><topic>Tetradecanoylphorbol Acetate - pharmacology</topic><topic>Tumor Necrosis Factor-alpha - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morisaki, N.</creatorcontrib><creatorcontrib>Takahashi, K.</creatorcontrib><creatorcontrib>Shiina, R.</creatorcontrib><creatorcontrib>Zenibayashi, M.</creatorcontrib><creatorcontrib>Otabe, M.</creatorcontrib><creatorcontrib>Yoshida, S.</creatorcontrib><creatorcontrib>Saito, Y.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morisaki, N.</au><au>Takahashi, K.</au><au>Shiina, R.</au><au>Zenibayashi, M.</au><au>Otabe, M.</au><au>Yoshida, S.</au><au>Saito, Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Platelet-Derived Growth Factor Is a Potent Stimulator of Expression of Intercellular Adhesion Molecule-1 in Human Arterial Smooth Muscle Cells</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1994-04-15</date><risdate>1994</risdate><volume>200</volume><issue>1</issue><spage>612</spage><epage>618</epage><pages>612-618</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><coden>BBRCA9</coden><abstract>The effects of platelet-derived growth factor (PDGF) on the expression of intercellular adhesion molecule-1(ICAM-1) as an indicator of cell activation were investigated in cultured human arterial smooth muscle cells(SMC). PDGF-BB and -AB but not -AA at 2-10 ng/ml stimulated ICAM-1 expression at a subconfluent but not a confluent state in a dose-dependent manner. ICAM-1 expression was induced at 2h, reached a plateau at 4h, and continued for at least 24h after stimulation with PDGF. The maximal stimulatory effect of PDGF-BB at 10 ng/ml was comparable to that by optimal concentrations of other cytokines and inflammatory agents. These data suggested that PDGF was a potent stimulator of ICAM-1.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>7909437</pmid><doi>10.1006/bbrc.1994.1492</doi><tpages>7</tpages></addata></record> |
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| subjects | Antigens, CD - biosynthesis Arteries - drug effects Arteries - metabolism Biological and medical sciences Cell Adhesion Molecules - biosynthesis Cell physiology Cells, Cultured Cytokines - pharmacology Enzyme-Linked Immunosorbent Assay Fundamental and applied biological sciences. Psychology Gene Expression - drug effects Humans Intercellular Adhesion Molecule-1 Interleukin-1 - pharmacology Interleukin-4 - pharmacology Kinetics Lipopolysaccharides - pharmacology Molecular and cellular biology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Phospholipases A - pharmacology Platelet-Derived Growth Factor - pharmacology Proto-Oncogene Proteins c-sis Recombinant Proteins - pharmacology Responses to growth factors, tumor promotors, other factors Structure-Activity Relationship Tetradecanoylphorbol Acetate - pharmacology Tumor Necrosis Factor-alpha - pharmacology |
| title | Platelet-Derived Growth Factor Is a Potent Stimulator of Expression of Intercellular Adhesion Molecule-1 in Human Arterial Smooth Muscle Cells |
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