Platelet-Derived Growth Factor Is a Potent Stimulator of Expression of Intercellular Adhesion Molecule-1 in Human Arterial Smooth Muscle Cells

The effects of platelet-derived growth factor (PDGF) on the expression of intercellular adhesion molecule-1(ICAM-1) as an indicator of cell activation were investigated in cultured human arterial smooth muscle cells(SMC). PDGF-BB and -AB but not -AA at 2-10 ng/ml stimulated ICAM-1 expression at a subconfluent but not a confluent state in a dose-dependent manner. ICAM-1 expression was induced at 2h, reached a plateau at 4h, and continued for at least 24h after stimulation with PDGF. The maximal stimulatory effect of PDGF-BB at 10 ng/ml was comparable to that by optimal concentrations of other cytokines and inflammatory agents. These data suggested that PDGF was a potent stimulator of ICAM-1.