Copper‐mediated annulation of 2‐aminoacetophenones and 2‐bromopyridines
A simple, practical method for synthesis of pyrido‐fused quinazolinones is herein developed. Reactions of 2’‐aminoacetophenones and 2‐bromopyridines proceeded in the presence of Cu(OAc)2 catalyst, NaOAc base, TEMPO co‐oxidant, and DMSO solvent. Simple functional groups were compatible with reaction...
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| Veröffentlicht in: | Vietnam journal of chemistry 2022-04, Vol.60 (2), p.164-168 |
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| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
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| Online-Zugang: | Volltext |
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| Zusammenfassung: | A simple, practical method for synthesis of pyrido‐fused quinazolinones is herein developed. Reactions of 2’‐aminoacetophenones and 2‐bromopyridines proceeded in the presence of Cu(OAc)2 catalyst, NaOAc base, TEMPO co‐oxidant, and DMSO solvent. Simple functional groups were compatible with reaction conditions. |
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| ISSN: | 0866-7144 2572-8288 2572-8288 |
| DOI: | 10.1002/vjch.202100091 |