Cover Picture: Gingival mesenchymal stem cells derived from patients with rheumatoid arthritis treat experimental arthritis (View 6/2024)

In article number 20240021, the authors demonstrate that GMSC derived from patients with Rheumatoid Arthritis shared a similar expression of Immunophenotype with that from health donors. Survived for at least 24 days in a CIA mouse model following injection, RA GMSC reduced the joint histopathologic...

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Veröffentlicht in:View (Beijing, China) China), 2024-12, Vol.5 (6), p.n/a
Hauptverfasser: Hou, Yuluan, Zhang, Ximei, Zeng, Donglan, Zhu, Shangling, Luo, Yang, Dang, Junlong, Wu, Wenbin, Xiong, Yiding, Zhao, Jun, Huang, Jianlin, Yuan, Jia, Wang, Shuhong, Wang, Julie, Xu, Hanshi, Zhang, Wei, Ai, Hong, Chen, Zheng, Zheng, Song Guo
Format: Artikel
Sprache:eng
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Zusammenfassung:In article number 20240021, the authors demonstrate that GMSC derived from patients with Rheumatoid Arthritis shared a similar expression of Immunophenotype with that from health donors. Survived for at least 24 days in a CIA mouse model following injection, RA GMSC reduced the joint histopathological scores of lymphocytes, osteoclasts, and cartilages. RA‐GMSCs were also effective in suppressing inflamed synoviocyte in a humanized synovitis model as health GMSC does. As a new Elixir from RA patients, autologous GMSCs may have a promising therapeutic potential in patients with RA.
ISSN:2688-3988
2688-268X
DOI:10.1002/viw2.388