Cardiac hemodynamics in fetuses with transposition of the great arteries and intact ventricular septum from diagnosis to end of pregnancy: longitudinal follow‐up

ABSTRACT Objectives Little is known about cardiac hemodynamics in the fetus with transposition of the great arteries and intact ventricular septum (TGA‐IVS). Better understanding of the fetal physiology in TGA‐IVS would help to provide insights into specific clinical complications observed after birth, in particular neonatal hypoxia and pulmonary hypertension. The aim of this study was to assess cardiac hemodynamics in fetuses with TGA‐IVS by performing systematic longitudinal echocardiographic follow‐up from diagnosis to delivery. Methods This was a longitudinal retrospective study of fetuses referred between 2010 and 2018 to the Sainte‐Justine University Hospital Centre. Complete assessment of cardiac hemodynamics was performed in fetuses with TGA‐IVS at 18–22, 28–32 and 35–38 weeks' gestation, which were compared with normal fetuses matched for gestational age. The maximum diameter of the foramen ovale was measured using two‐dimensional echocardiography under the guidance of color Doppler echocardiography. Fetal cardiac hemodynamics were analyzed according to postnatal preductal transcutaneous oxygen saturation (TcSO2)