Experimental production of congenital cardiovascular malformations in rats by salicylate poisoning
Congenital cardiovascular malformations were produced in offspring of rats that received salicylates during the organogenetic period of gestation. The most frequent anomalies encountered were transposition of the aorta to the right ranging from “overriding of the aorta” to complete transposition. Th...
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| Veröffentlicht in: | Teratology (Philadelphia) 1968-02, Vol.1 (1), p.109-117 |
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| container_title | Teratology (Philadelphia) |
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| creator | Takacs, Eva Warkany, Josef |
| description | Congenital cardiovascular malformations were produced in offspring of rats that received salicylates during the organogenetic period of gestation. The most frequent anomalies encountered were transposition of the aorta to the right ranging from “overriding of the aorta” to complete transposition. The doses necessary to produce such malformations in rats are compared with those used in human beings for therapeutic and suicidal purposes. |
| doi_str_mv | 10.1002/tera.1420010112 |
| format | Article |
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The doses necessary to produce such malformations in rats are compared with those used in human beings for therapeutic and suicidal purposes.</description><subject>Abnormalities, Drug-Induced - etiology</subject><subject>Animals</subject><subject>Aorta - abnormalities</subject><subject>Aspirin - administration & dosage</subject><subject>Dextrocardia - chemically induced</subject><subject>Female</subject><subject>Fetal Heart - abnormalities</subject><subject>Gestational Age</subject><subject>Maternal-Fetal Exchange</subject><subject>Pregnancy</subject><subject>Rats</subject><subject>Salicylates - poisoning</subject><subject>Transposition of Great Vessels - chemically induced</subject><issn>0040-3709</issn><issn>1096-9926</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1968</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM9LwzAYhoMoOqdnT0L-gc78aNMGTyrTCWPCUBQv4WuSSrRrStLp9t-7UZl48vQd3vd54XsQOqNkRAlhF50NMKIpI4QSStkeGlAiRSIlE_toQEhKEp4TeYSOY3zvS_wQHWZCioLyASrHq9YGt7BNBzVugzdL3TnfYF9h7Zs327htoCEY5z8h6mUNAS-grnxYwLYZsWtwgC7ico0j1E6va-gsbr2LvnHN2wk6qKCO9vTnDtHT7fjxZpJMH-7ub66miWYyZwmzVpcmM2lFJdXcQsFS0BpyLo2ouGa6tFZSljNTEAJGcFMJItO0gEyUhvIhuuh3dfAxBlupdvMYhLWiRG1lqa0s9StrQ5z3RLssF9bs-j92Nvlln3-52q7_m1OP4_nVn_Wkp13s7GpHQ_hQIud5pp5nd-p6_poW2eRFzfg3WjuJVQ</recordid><startdate>196802</startdate><enddate>196802</enddate><creator>Takacs, Eva</creator><creator>Warkany, Josef</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>196802</creationdate><title>Experimental production of congenital cardiovascular malformations in rats by salicylate poisoning</title><author>Takacs, Eva ; Warkany, Josef</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2972-2eecbd5d4f191c3ea824acca739d6f3c2cbee91272d800ad63df609448a56bd13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1968</creationdate><topic>Abnormalities, Drug-Induced - etiology</topic><topic>Animals</topic><topic>Aorta - abnormalities</topic><topic>Aspirin - administration & dosage</topic><topic>Dextrocardia - chemically induced</topic><topic>Female</topic><topic>Fetal Heart - abnormalities</topic><topic>Gestational Age</topic><topic>Maternal-Fetal Exchange</topic><topic>Pregnancy</topic><topic>Rats</topic><topic>Salicylates - poisoning</topic><topic>Transposition of Great Vessels - chemically induced</topic><toplevel>online_resources</toplevel><creatorcontrib>Takacs, Eva</creatorcontrib><creatorcontrib>Warkany, Josef</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Teratology (Philadelphia)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takacs, Eva</au><au>Warkany, Josef</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental production of congenital cardiovascular malformations in rats by salicylate poisoning</atitle><jtitle>Teratology (Philadelphia)</jtitle><addtitle>Teratology</addtitle><date>1968-02</date><risdate>1968</risdate><volume>1</volume><issue>1</issue><spage>109</spage><epage>117</epage><pages>109-117</pages><issn>0040-3709</issn><eissn>1096-9926</eissn><abstract>Congenital cardiovascular malformations were produced in offspring of rats that received salicylates during the organogenetic period of gestation. 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| fulltext | fulltext |
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| ispartof | Teratology (Philadelphia), 1968-02, Vol.1 (1), p.109-117 |
| issn | 0040-3709 1096-9926 |
| language | eng |
| recordid | cdi_crossref_primary_10_1002_tera_1420010112 |
| source | Wiley-Blackwell Journals; MEDLINE |
| subjects | Abnormalities, Drug-Induced - etiology Animals Aorta - abnormalities Aspirin - administration & dosage Dextrocardia - chemically induced Female Fetal Heart - abnormalities Gestational Age Maternal-Fetal Exchange Pregnancy Rats Salicylates - poisoning Transposition of Great Vessels - chemically induced |
| title | Experimental production of congenital cardiovascular malformations in rats by salicylate poisoning |
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